London, Oct.14 (ANI): Spanish Formula One racer Fernando Alonso has warned key rival Lewis Hamilton of Britain that he will be back to haunt him and wreck his title dream.

The Spaniard has vowed to wreak revenge on his former teammate Hamilton by helping Hamilton's rival Felipe Massa in the two-race showdown for the drivers' crown.

The duo was at war last season after Alonso accused McLaren of favouring the rookie because he was English in a British team.

Hamilton got the better on the track, finishing ahead of the double world champ in the standings, and off it as McLaren sacked Alonso, reports The Sun.

Alonso warned: "Yes, there is no doubt. If I can help, I will help Massa. Hamilton and Massa have lost a lot of points. After 16 races the leader has 84 points. In 2006 I had 82 in nine races.

"But in the end the one who makes the least errors will win. We'll see."

Hamilton leads Massa by just five points after his first-corner error in Fuji on Sunday earned him a drive through penalty. (ANI)

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Washington, Oct 22 (ANI): Studying an animal model of chronic inflammation and skin cancer, scientists have now found that inflammation can actually prevent skin cancer.

Inflammation is the frontline defence of the body against infection or disease.

According to researchers at Medical College of Georgia, IDO, an enzyme that works like a firefighter to keep inflammation under control, can be captured to protect early malignant cells

"Inflammation should really help prevent a tumour. You want a good immune response; this is what protects you from pathogens," he says. "In this case, it's an unfortunate exploitation by malignant cells," says Dr. Andrew Mellor, director of the MCG Immunotherapy Center and Georgia Research Alliance Eminent Scholar in Molecular Immunogenetics.

In fact, the researchers found strong evidence that inflammation triggers the immune response.

In the study, the researchers gave mice a single dose of a carcinogen right at the moment when they started painting a tiny portion of skin with a poison ivy derivative twice weekly for 20 weeks.

The mix quickly produced IDO and created a "suppressive" immune response that helped resulting precancerous cells grow into tumors. However, employing the same protocol in a mouse in which IDO had been genetically deleted, dramatically slowed tumour development.

The significance of the new study is that the researchers have shown that IDO, or indoleomine 2,3-dioxygenase, may be produced as a part of the inflammatory mix, which could then protect the malignant skin cells.

"'Chronic' is the key word. We have long suspected that IDO is a component of certain kinds of inflammation that create suppression," said Mellor.

He speculated that IDO's "firefighter" role probably resulted from the body's need to control inflammation in areas such as the gastrointestinal tract. The GI tract is constantly bombarded by food and microbes which could lead to debilitating and deadly inflammation.

The new research, according to Mellor, showed that IDO has a more important and earlier role than we thought in tumor formation.

"IDO favors the tumor: The immune system basically sits back and watches the tumor grow," said Mellor.

The study is published online in Proceedings of the National Academy of Sciences. (ANI)

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London, Oct 23 (ANI): Scientists at Newcastle University have now unravelled the mechanism by which the fundamental building blocks of life, proteins and metals, bind together.

Lead author Professor Nigel Robinson has revealed the mechanism, which ensures that the right metal goes to the right protein.

Life, microbe, plant or human, are all made up of atoms, which include metals such as copper and manganese which act as catalysts in proteins, which in turn around the metal atoms.

In their study, the researchers had shown that copper and manganese protein wrap around the correct metal atoms in different parts of the cell, which are zones containing different metals. Thus, which protein attaches to which metal is determined by where the folding action takes place in the cell.

Earlier scientists believed that the right metals were simply those, which were most attracted to the protein, but the new study led by Professor Nigel Robinson at Newcastle University, might change this perception.

"This has taken us one step closer to understanding why metals and proteins assemble in the ways they do," Nature quoted Robinson as saying.

He added: "One motive behind the work is pure curiosity, but as so many proteins need metals this type of work has many potential uses - for example, in synthetic biology which is striving to produce green power from bacteria by using energy from sunlight to produce hydrogen gas, a process which needs nickel and iron.

"It may also help in diseases such as Alzheimers where there are unexplained links to proteins binding metals such as copper. There's also application in controlling infections by Staphylococcus aureus; a bacterium which our bodies defences succeed - or sometimes fail - in killing by removing manganese and zinc from abscesses."

In the study, it was demonstrated that the way the metals attach is identical for a protein that binds manganese to one that binds copper. In both cases the metals bind inside protein barrels with the same type of metal-attractions.

The researchers carried out the work in a blue-green algae, a cyanobacterium, and showed that a protein requiring copper transports to the periplasm, the outer area of the cell, where it then folds around the available metal, which is copper.

On the other hand, manganese and not copper atoms are found in the cytosol, in the middle of the cell. They showed that a protein requiring manganese folds in the cytosol. The manganese protein is then transported to the periplasm having first trapped its manganese.

In the new study, the researchers first developed a new approach to discover metal-binding proteins, which is now being swiftly applied to lots of other types of living cells and other essential metals (zinc, nickel, cobalt, iron).

The study is published in the recent issue of Nature. (ANI)

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Melbourne, Oct 23 (ANI): When it comes to getting the perfect pose or look, even a piece of bread will come in handy, according to 'Make Me A Supermodel' stylist Tiana Wallace.

According to Tiana, bread is very vital to a man in underwear, as just one slice wedged in the front of a pair of briefs will give the sought-after "smooth look."

Though Confidential will not confirm if David Beckham used the method for his steamy Armani campaign earlier this year, finalist Rhys Uhlich was chosen to make a test-run.

From the taping, which is to be aired on the October 23 episode of Make Me A Supermodel, there was proof enough about what Wallace said.

The secret trick left host Jennifer Hawkins amazed that it actually worked.

"I actually learnt something that day," the Daily Telegraph quoted her as saying. (ANI)

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